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authors moore lipp griffiths and abernethy are with the us pharmacopeial convention 12601 twinbrook parkway rockville md 20852 1790 u s a author devries is a member of the us pharmacopeial convention s food ingredients expert committee, crispr cas9 knockin mice for genome editing and cancer - introduction molecular genetic studies are continuously transforming our knowledge in biology and medicine forward and reverse genetics in cells and animal models is key to discovering causal mechanisms relating molecular events to phenotypes griffiths 2012 traditionally genetic manipulations in mammalian species are often made in the germline of an organism which can then be used to, primary care of adults with intellectual and developmental - objective to update the 2011 canadian guidelines for primary care of adults with intellectual and developmental disabilities idd methods family physicians and other health professionals experienced in the care of people with idd reviewed and synthesized recent empirical ecosystem expert and experiential knowledge a system was developed to grade the strength of recommendations, colon cancer practice essentials background pathophysiology - 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